Linking RNA Secondary Structure to the Free Energy of Tertiary Structure Folding through Coarse-Grained Models
نویسندگان
چکیده
منابع مشابه
Tertiary Motifs in RNA Structure and Folding.
Specific tertiary structural motifs determine the complete architecture of RNA molecules (see picture for examples). Within the last few years a number of high-resolution crystal structures of complex RNAs have led to new insights into the mechanisms by which these complex folds are attained. In this review the structures of these tertiary motifs and how they influence the folding pathway of bi...
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Optimal exploitation of the expanding database of sequences requires rapid finding and folding of RNAs. Methods are reviewed that automate folding and discovery of RNAs with algorithms that couple thermodynamics with chemical mapping, NMR, and/or sequence comparison. New functional noncoding RNAs in genome sequences can be found by combining sequence comparison with the assumption that function...
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Algorithms for prediction of RNA secondary structure— the set of base pairsthat form when an RNA molecule folds— are valuable to biologists who aim tounderstand RNA structure and function. Improving the accuracy and efficiencyof prediction methods is an ongoing challenge, particularly for pseudoknottedsecondary structures, in which base pairs overlap. This challenge is biologica...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2014
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2013.11.1661